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Tadalafil treatment for erectile dysfunction

Erectile problems are very commonly seen in men worldwide. It can occur due to multiple causes and reasons.

The treatment for Erectile Dysfunction (ED) was revolutionized with the development of Phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil is a versatile PDE5 inhibitor in the clinical management of Erectile Dysfunction. Clinical trials have proven its safety and efficacy as regards dosing strategies, for all severities and aetiologies of ED.

Erection Mechanism:

Erection is achieved by increasing blood flow to the spongy penile tissues, temporarily when you are sexually aroused. The release of nitric oxide (NO) from nerve terminals and endothelial cells of the penis stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum of the penis which in turn produces Penile erection during sexual stimulation.

What are the Benefits (Uses) of Tadalafil Tablets?

  • Tadalafil is used to treat male sexual function problems such as Erectile Dysfunction.
  • Tadalafil is thought to work by relaxing the smooth muscle in the Prostate and Bladder which helps in treating BPH ( Benign Prostate Hypertrophy).
  • Tadalafil in greater doses will also help in treating Pulmonary Hypertension.

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Pharmacokinetics:

Tadalafil is rapidly absorbed in blood after oral administration and attains a bioavailability of 61%. It is metabolized majorly by liver enzymes and excreted through both urine and fecal matter.

Dosage: How To Take Tadalafil Tablets?

Following are the dosage regimen for Tadalafil:

Disease Initial Dose Maintenance Dose Maximum Dose
Erectile Dysfunction [ED] 10 mg once a day.
1 hour prior to sexual contact.
10 mg once a day 1 hour prior to sexual contact. Tadalafil more than 10 mg per day will not show a greater effect in treating Erectile Dysfunction.
Benign Prostate Hyperplasia [BPH] 5 mg once a day. 2.5 mg once a day. Tadalafil more than 5 mg per day has no effect on prostate enlargement.
Pulmonary Hypertension [PAH] 20-40 mg once daily. 20 mg once a day. Tadalafil more than 40 mg per day for prolonged use may lead to side effects.

Are there Any Side Effects with Tadalafil Tablets?

Following side effects may occur in some people, especially if you take higher doses.

  • Headache
  • Dizziness
  • Indigestion
  • Stuffy nose
  • Blurred vision

Drug-Food Interaction:

Eating grapefruit or drinking grapefruit juice may increase the levels of tadalafil in your blood. This raises your risk of side effects.

Contraindication:

Tadalafil is contraindicated in patients receiving Anti-anginal and Anti-viral medications. Always follow as per doctors’ advice.

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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a healthcare provider.

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